Gene information
Official symbol IGFBP3
Official full name insulin like growth factor binding protein 3
Gene type protein-coding gene
Chromosome7p12.3
Alias symbolIBP3; BP-53
Gene familyInsulin like growth factor binding proteins
Resources
Entrez Gene 3486
HGNC HGNC:5472
Ensembl ENSG00000146674
Vega OTTHUMG00000023769
UCSC uc003tns.4
GO terms: 24 records
GO Description Category LogP Number of genes Detail
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001968 fibronectin binding GO Molecular Functions -9.79576986 9 More
GO:0005520 insulin-like growth factor binding GO Molecular Functions -5.13373504 7 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0008047 enzyme activator activity GO Molecular Functions -1.49794348 13 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014910 regulation of smooth muscle cell migration GO Biological Processes -16.4082106 27 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031994 insulin-like growth factor I binding GO Molecular Functions -5.14025860 6 More
GO:0031995 insulin-like growth factor II binding GO Molecular Functions -3.92643717 3 More
GO:0036454 growth factor complex GO Cellular Components -4.12631862 3 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO Biological Processes -9.31062473 8 More
GO:0045661 regulation of myoblast differentiation GO Biological Processes -4.24103271 7 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048662 negative regulation of smooth muscle cell proliferation GO Biological Processes -21.7509412 30 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04115 p53 signaling pathway KEGG Pathway -6.32340535 9 More
hsa04935 Growth hormone synthesis, secretion and action KEGG Pathway -2.82078524 13 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
Drug-Gene interaction
view
Related drugs: 2 records
Drug name Interaction type Source PMID View
celecoxib PharmGKB 22336956 view
fluorouracil PharmGKB 20860465 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
insulin-like growth factor-binding protein 3 proteomics age[other] myocardial infarction Reeves I et al. Growth Horm IGF Res. 2000
All rights reserved: Soochow University Center for Systems Biology